O2 stable hydrogenases for applications

Progress in catalysis research

Dr.James Birrell and Dr.Patricia Rodríguez Maciá (MPI CEC)

A team of researchers from the Max Planck Institute for Chemical Energy Conversion and the MPI für Kohlenforschung in Mülheim an der Ruhr have succeeded in optimizing naturally occurring catalysts (hydrogenases) for application.

The new findings mean that the highly oxygen-sensitive enzymes can now also be handled in the air and used in fuel cells or in electrolytic or photolytic water splitting.

This research provides a step forward towards the use of these enzymes in technological applications as well as in understanding the mechanism of inactivation by oxygen. It also provides clues for protecting synthetic molecular catalysts designed for hydrogen conversion and production.

The results were recently published in the Journal of the American Chemical Society:
Patricia Rodríguez-Maciá, Edward J. Reijerse, Maurice van Gastel, Serena DeBeer, Wolfgang Lubitz, Olaf Rüdiger, and James A. Birrell. Sulfide Protects [FeFe] Hydrogenases From O2 J. Am. Chem. Soc. (Just Accepted Manuscript) DOI: 10.1021/jacs.8b04339

You'll find a summary of the work in our press release as well.

The publication has also been highligted in Nature Catalysis.